Primary Sjogren's syndrome and aplastic anaemia

Primary Sjögren's syndrome and aplastic anaemia.

Primary Sjögren’s syndrome (SS) is an autoimmune disease characterised by the presence of xerostomia and xerophthalmia without evidence of another systemic autoimmune disease. It has a wide clinical spectrum, extending from exocrinopathy to systemic autoimmune disease and to B cell lymphoma. The association of SS with aplastic anaemia (AA) has rarely been reported 2 and only in patients with ly...

Primary Sjogrens Syndrome in a Child

Sjögren syndrome is uncommon in children and occurs most often in association with autoimmune diseases (secondary Sjögren syndrome). We describe the clinical and biological features of a 7-year-old girl with primary Sjögren syndrome revealed by recurrent parotiditis. CASE REPORT A 7-year-old girl was referred for investigation of multiple episodes of parotid swelling since age 4 years, withou...

Aplastic anaemia evolving into myelodysplastic syndrome.

Acquired aplastic anaemia is a clonal disorder of multifactonal origin. The ~pathophysiology of this disorder is still not clear Presumably the multiple incriminating factors include an intrinsic derangement of haematopoiesis, immune mediated damage to bone marrow and genetic predisposition. The long term complications of the aplastic anaemia include clonal evolution into disorders like Paroxys...

Aplastic Anaemia.

Aplastic anaemia: a review.

Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppress...